Objectives-To establish the incidence and severity of arterial oxygen
desaturation during transoesophageal echocardiography performed under
light intravenous sedation; to determine which patients are at greates
t risk; and to assess the effects of supplementary oxygen treatment. D
esign-Prospective study of 150 patients referred for transoesophageal
echocardiography. Setting-Echocardiography laboratory in a tertiary ca
rdiothoracic referral centre. Main outcome measure-Transcutaneous arte
rial oxygen saturation. Results-During transoesophageal echocardiograp
hy mean (SD) arterial oxygen saturation (Sao(2)) fell in 144 of 150 pa
tients (96%) from 95.4%(2.6%) to 90.7%(6.3%) (p < 0.001). Significant
hypoxaemia, defined as Sao, < 90%, was found in 27 of 150 patients (18
%); in this group Sao, fell from 92.9%(3.5%) to 81.8%(9.6%) (p < 0.001
), but rose rapidly on oxygen to 95.5%(2.4%) (p < 0.001). Two patients
became profoundly hyperaemic with SaO(2) values of 35% and 74%. The p
rincipal risk factors for hypoxaemia during transoesophageal echocardi
ography were mitral valve disease, severe mitral regurgitation, and Ne
w York Heart Association symptomatic class III or IV. Conclusions-Tran
scutaneous oximetry and supplementary oxygen should be available routi
nely during transoesophageal echocardiography.