In a prospective randomised study, the effect of acupuncture on sham f
eeding stimulated gastric acid secretion was investigated. In eight he
althy volunteers (five men, three women, mean (SEM) age 26.3 (4.7) yea
rs) various methods of acupuncture were performed. Apart from the sham
procedure, the acupuncture was performed at the classic acupuncture p
oints. Electroacupuncture reduced gastric acid secretion expressed as
median (range) significantly during the first 30 minute period to 1.6
(0-5.2) mmol compared with 3.8 (2.3-14.5) mmol (p < 0.05) during contr
ol period (sham feeding without acupuncture). Inhibition of gastric ac
id secretion by electroacupuncture was also significant during the sec
ond 30 minute period (0.2 (0-5.6) v 3.6 (0.3-9.1) mmol; p < 0.05) and
for peak acid output (0.8 (0.2-5.1) v 7.6 (3.4-12.1) mmol; p < 0.05).
Transcutaneous electrical nerve stimulation also resulted in significa
nt reduction of gastric acid secretion during the first 30 minute peri
od (1.0 (0-3.6) mmol v 3.8 (2.3-14.5) mmol; p < 0.05), and peak acid o
utput (3.6 (1.2-12.0) v 7.6 (3.4-12.1) mmol; p < 0.05). The classic ne
edle acupuncture, laser acupuncture, and sham acupuncture had no signi
ficant effect on gastric acid secretion. This study shows firstly that
in healthy volunteers, only the versions of acupuncture using more pr
onounced stimulation (electroacupuncture, transcutaneous electrical ne
rve stimulation), but not those with only mild stimulation of the nerv
es (classic needle acupuncture, laser acupuncture), and secondly only
acupuncture performed at defined points lead to significant reduction
in gastric acid secretion.