SYNTHESIS AND NEMATOCIDAL ACTIVITY OF ARYLMERCAPTOVINYLTETRAHYDROPYRIMIDINES

Authors
KRAOUTI N LABIDALLE S CAUJOLLE R PAYARD M BORIES C LOISEAU PM GAYRAL P
Citation
N. Kraouti et al., SYNTHESIS AND NEMATOCIDAL ACTIVITY OF ARYLMERCAPTOVINYLTETRAHYDROPYRIMIDINES, Il Farmaco, 49(5), 1994, pp. 371-373
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
49
Issue
5
Year of publication
1994
Pages
371 - 373
Database
ISI
SICI code
0014-827X(1994)49:5<371:SANAOA>2.0.ZU;2-3
Abstract
A set of mercaptovinyl tetrahydropyrimidines was synthesized in good y ields by lithiation of 1,2-dimethyltetrahydropyrimidine with n-butyl l ithium in tetrahydrofurane, followed by condensation with aromatic thi oesters. Against three nematode genera, anthelminthic screening shows little activity; 2b and 2d were the most potent against Molinema desse tae.