HPLC DETERMINATION OF SODIUM CROMOGLYCATE IN PHARMACEUTICAL DOSAGE FORMS

A reversed-phase high-performance liquid chromatography (HPLC) method is described for the determination of sodium chromoglycate (SCG) in bu lk drug and pharmaceutical dosage forms (capsules, solutions, gels). A liquots were chromatographed on C-18 columns using methanol: phosphate buffer (50:50 v/v) at pH 2.3 as the mobile phase. Detection was perfo rmed at 326 nm with a linear range of 0.05-0.5 mug/ml (r = 0.9999). Re covery values ranged from 99.21 to 106.31% (N = 9). The proposed metho d is rapid and simple, free from interference by excipient and degrada tion products, and can be recommended for routine control analysis of sodium chromoglycate commercial products and magistral formulations .