ANALYSIS OF TRIMETHOPRIM - SULFONAMIDE DRUG-COMBINATIONS IN DOSAGE FORMS BY UV SPECTROSCOPY AND LIQUID-CHROMATOGRAPHY (HPLC)

Authors
BONAZZI D ANDRISANO V DIPIETRA AM CAVRINI V
Citation
D. Bonazzi et al., ANALYSIS OF TRIMETHOPRIM - SULFONAMIDE DRUG-COMBINATIONS IN DOSAGE FORMS BY UV SPECTROSCOPY AND LIQUID-CHROMATOGRAPHY (HPLC), Il Farmaco, 49(6), 1994, pp. 381-386
Citations number
38
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
49
Issue
6
Year of publication
1994
Pages
381 - 386
Database
ISI
SICI code
0014-827X(1994)49:6<381:AOT-SD>2.0.ZU;2-Q
Abstract
Derivative and difference spectrophotometric methods are described for the direct, simultaneous analysis of combinations of Trimethoprim wit h sulfonamide drugs (sulfadiazine, sulfamethoxazole, sulfamethoxypyrid azine) in commercial dosage forms. The more advantageous approach (der ivative and difference mode) is suggested for each binary mixture. The assay results are compared with those obtained by a new chromatograph ic (HPLC) method, involving a C-18 column and a mobile phase (pH 6.5) containing 1,8 diaminooctane as amine modifier and sodium heptansulfon ate as ion pairing agent.