USE OF CAPILLARY ELECTROPHORESIS FOR TESTING THE STABILITY OF A DRUGSMIXTURE IN PERFUSIONAL SOLUTION

The quantitative analysis of aminophylline, methylprednisolone-21-hemi succinate and furosemide in perfusional solution by capillary electrop horesis is described. The electrophoretic runs performed in phosphate buffer at pH 8 allowed the separation of aminophylline, methylpredniso lone-21-hemisuccinate and furosemide. In order to improve the selectiv ity of the separation of the three drugs from their degradation produc ts, the background electrolyte was supported with 30 mM of sodium dode cyl sulfate (SDS). Reproducibility standard deviations of migration ti mes and peak area ratios (internal standard method was used for quanti tation) were in the range 0.25%-2.98%. UV spectra have been made in or der to confirm the identity of the degradation products.