REVERSIBLE NEUROTOXICITY OF INTERLEUKIN-2 AND TUMOR-NECROSIS-FACTOR -CORRELATION OF SPECT WITH NEUROPSYCHOLOGICAL TESTING

Authors
MEYERS CA VALENTINE AD WONG FCL LEEDS NE
Citation
Ca. Meyers et al., REVERSIBLE NEUROTOXICITY OF INTERLEUKIN-2 AND TUMOR-NECROSIS-FACTOR -CORRELATION OF SPECT WITH NEUROPSYCHOLOGICAL TESTING, The Journal of neuropsychiatry and clinical neurosciences, 6(3), 1994, pp. 285-288
Citations number
23
Categorie Soggetti
Neurosciences,Psychiatry
Journal title
The Journal of neuropsychiatry and clinical neurosciences → ACNP
ISSN journal
08950172
Volume
6
Issue
3
Year of publication
1994
Pages
285 - 288
Database
ISI
SICI code
0895-0172(1994)6:3<285:RNOIAT>2.0.ZU;2-R
Abstract
A 41-year-old man developed subacute neurotoxicity associated with int erleukin-2 and tumor necrosis factor therapy for metastatic renal cell carcinoma. Cognitive deficits revealed on neuropsychological testing and frontal lobe perfusion deficits revealed on SPECT resolved after 1 month. Findings suggest possible neuroanatomic and physiologic substr ates of cytokine neurotoxicity.