ANTI-ANNEXIN-V ANTIBODY IN SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS WITHLUPUS ANTICOAGULANT AND OR ANTICARDIOLIPIN ANTIBODY/

Authors
MATSUDA J SAITOH N GOHCHI K GOTOH M TSUKAMOTO W
Citation
J. Matsuda et al., ANTI-ANNEXIN-V ANTIBODY IN SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS WITHLUPUS ANTICOAGULANT AND OR ANTICARDIOLIPIN ANTIBODY/, American journal of hematology, 47(1), 1994, pp. 56-58
Citations number
8
Categorie Soggetti
Hematology
Journal title
American journal of hematology → ACNP
ISSN journal
03618609
Volume
47
Issue
1
Year of publication
1994
Pages
56 - 58
Database
ISI
SICI code
0361-8609(1994)47:1<56:AAISLP>2.0.ZU;2-S
Abstract
We investigated anti-annexin V antibody (aANX) in patients with system ic lupus erythematosus (SLE), and correlated to positivity with lupus anticoagulant (LA)/anticardiolipin antibody (aCL). aANX was positive i n 12/47 SLE patients (26%), including 7 with beta(2)-glycoprotein 1 (G PI)-dependent aANX. The positivity of aANX was higher in patients with aCL (19%) and LA/aCL (50%) than in those without LA/aCL (10%). From t hese results, it is concluded that aANX is an autoantibody closely rel ated to LA/aCL, and can be a possible new risk marker for thrombosis. (C) 1994 Wiley-Liss, Inc.