A NEW ROUTE TO THE ANTITUMOR DRUG TEMOZOLOMIDE, BUT NOT THIOTEMOZOLOMIDE

Authors
WANG YF LOWE PR THOMSON WT CLARK J STEVENS MFG
Citation
Yf. Wang et al., A NEW ROUTE TO THE ANTITUMOR DRUG TEMOZOLOMIDE, BUT NOT THIOTEMOZOLOMIDE, Chemical communications, (4), 1997, pp. 363-364
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
4
Year of publication
1997
Pages
363 - 364
Database
ISI
SICI code
1359-7345(1997):4<363:ANRTTA>2.0.ZU;2-E
Abstract
Interaction of 5-aminoimidazole-4-carboxamide with alkyl isocyanates y ields N-substituted 1-carbamoylimidazoles which can be cyclised to imi dazo[5,1-d][1,2,3,5]tetrazin-4(3H)-ones, including temozolomide 3a, on nitrosation; a similar reaction with methyl isothiocyanate, followed by nitrosation, affords the nitrosomethylamino derivative 11 of a new ring-system, imidazo[1,5-b][1,2,4]thiadiazole.