A NEW METHOD FOR F-18 LABELING OF BIOCHEMICAL-MOLECULES USING [F-18] PERFLUORONITROBENZENE AND ITS APPLICATION TO F-18 LABELING OF ANGIOTENSIN-II

Authors
HASHIZUME K TAMAKAWA H HASHIMOTO N MIYAKE Y
Citation
K. Hashizume et al., A NEW METHOD FOR F-18 LABELING OF BIOCHEMICAL-MOLECULES USING [F-18] PERFLUORONITROBENZENE AND ITS APPLICATION TO F-18 LABELING OF ANGIOTENSIN-II, Chemistry Letters, (2), 1997, pp. 109-110
Citations number
8
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
2
Year of publication
1997
Pages
109 - 110
Database
ISI
SICI code
0366-7022(1997):2<109:ANMFFL>2.0.ZU;2-5
Abstract
We propose a new method for labeling biochemical molecules with flouri ne-18 (positron emitters) using [G-F-18]polyfluoronitrobenzene as the reagent. Perfluoronitrobenzene was easily labeled with F-18(-) by the F-18-for-F-19 exchange reaction giving [G-F-18]pentafluoronitrobenzene (PFNB, radiochemical yield 30-41%) and the [G-F-18]PFNB was applied s uccessfully for F-18-labeling of angiotensin II.