P. Janowitz et al., GALLBLADDER SLUDGE - SPONTANEOUS COURSE AND INCIDENCE OF COMPLICATIONS IN PATIENTS WITHOUT STONES, Hepatology, 20(2), 1994, pp. 291-294
Although the ultrasonic detection of gallbladder sludge is relatively
frequent, its clinical importance remains unclear, partly because of t
he paucity of reliable investigations regarding its natural course in
patients without stones. In a retrospective study we investigated the
course and clinical significance of gallbladder sludge in patients wit
hout stones or other identified gallbladder abnormalities. The diagnos
is of gallbladder sludge was made by ultrasound scan in 286 (1.7%) of
17,021 patients. The mean follow-up period for these patients was 20.3
+/- 11.5 mo. Of this group 56 patients were without both stones and s
ludge at the initial examination, and gallbladder sludge developed aft
er a mean observation period of 11.2 +/- 10.6 mo. Within 2.0 +/- 3.5 m
o after sludge detection, 40 (71.4%) patients were free of sludge and
showed normal gallbladder findings. Gallbladder stones without sludge
persistence developed in five patients (8.9%) within 2.5 +/- 0.6 mo af
ter diagnosis of sludge, and gallstones with persistence of sludge dev
eloped in two other patients (3.6%) after 6.1 and 30.7 mo, respectivel
y. In no cases did the stones become clinically symptomatic in the cou
rse of the follow-up period. Acute acalculous cholecystitis developed
in four patients (7.1%) from 6.5 to 37.5 mo after the first examinatio
n. In five patients, sludge persisted after a mean 22.3 +/- 13.5 mo of
follow-up. Although our data show that gallbladder sludge disappeared
spontaneously within a relatively short time in 71.4% of patients, ga
llbladder sludge must be considered an important pathologic entity bec
ause gallbladder stones or complications such as acute cholecystitis o
ccurred in 19.6% of patients. It remains for prospective studies to in
vestigate whether therapy of gallbladder sludge may reduce the inciden
ce of complications, particularly the development of gallstones and ac
ute cholecystitis. We were not able to observe acute pancreatitis at l
east for the first year after sludge development.