IMPAIRMENT OF GASTRIC-MUCOSAL DEFENSES MEASURED IN-VIVO IN CIRRHOTIC RATS

Patients with cirrhosis have an increased incidence of gastric ulcers and erosions. We evaluated the effect of carbon tetrachloride-induced cirrhosis on rat gastric mucosal defense mechanisms using our recently developed in vivo fluorescence microscopy technique. Cirrhotic rats h ad increased portal vein pressure, increased serum aminotransferase co ncentrations and decreased serum albumin concentrations. We noted sign ificantly more spontaneous gross gastric lesions in the cirrhotic rats . In vivo microscopic measurements revealed that cirrhotic rats had (a ) a significantly thinner gastric mucous gel layer, (b) a much greater decrease in surface mucosal cell intracellular pH in response to an a cid load, (c) decreased gastric mucosal blood how and (d) decreased su rface cell viability. We conclude that spontaneous gastric mucosal les ions in cirrhotic rats may be related to more rapid penetration of aci d through a thinner gastric mucous gel layer and a lower mucosal blood flow. These changes are associated with a decreased ability of the su rface cells to maintain intracellular pH homeostasis, increased initia l gastric surface cell acidification, decreased surface cell viability and a lower blood flow that probably is inadequate to remove the incr eased acid.