CHLOMIPRAMINE DIFFERENTLY AFFECTS INFLAMMATORY EDEMA AND PAIN IN THE RAT

Authors
BIANCHI M SACERDOTE P PANERAI AE
Citation
M. Bianchi et al., CHLOMIPRAMINE DIFFERENTLY AFFECTS INFLAMMATORY EDEMA AND PAIN IN THE RAT, Pharmacology, biochemistry and behavior, 48(4), 1994, pp. 1037-1040
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology, biochemistry and behavior → ACNP
ISSN journal
00913057
Volume
48
Issue
4
Year of publication
1994
Pages
1037 - 1040
Database
ISI
SICI code
0091-3057(1994)48:4<1037:CDAIEA>2.0.ZU;2-4
Abstract
In the rat, the acute administration of the antidepressant drug chlomi pramine significantly reduces the edema and the hyperalgesia induced b y yeast injection in the paw. However, the intensity and time course o f the two effects differ. Moreover, adrenalectomy enhances the antinoc iceptive effect, whereas it does not affect the antiedema action of ch lomipramine. Our data suggest a dissociation between the antiinflammat ory and the analgesic effect of acute chlomipramine.