PALLADIUM-CATALYZED CYCLIZATION OF 2-ALKYNYLANILINES TO 2-SUBSTITUTEDINDOLES UNDER AN ACIDIC 2-PHASE SYSTEM

Authors
CACCHI S CARNICELLI V MARINELLI F
Citation
S. Cacchi et al., PALLADIUM-CATALYZED CYCLIZATION OF 2-ALKYNYLANILINES TO 2-SUBSTITUTEDINDOLES UNDER AN ACIDIC 2-PHASE SYSTEM, Journal of organometallic chemistry, 475(1-2), 1994, pp. 289-296
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear
Journal title
Journal of organometallic chemistry → ACNP
ISSN journal
0022328X
Volume
475
Issue
1-2
Year of publication
1994
Pages
289 - 296
Database
ISI
SICI code
0022-328X(1994)475:1-2<289:PCO2T2>2.0.ZU;2-5
Abstract
The cyclization of 2-alkynylanilines in the presence of PdCl2 and nBu4 NCl under an acidic CH2Cl2-HCI two-phase system affords 2-substituted indoles in good to high yield, at room temperature. The reaction is pa rticularly suited to the one-flask preparation of 2-substituted indole s from 2-ethynylaniline.