IMMUNOREACTIVITY FOR BCL-2 PROTEIN IN MALIGNANT MESOTHELIOMA AND NONNEOPLASTIC MESOTHELIUM

Authors
SEGERS K RAMAEL M SINGH SK WEYLER J VANMEERBEECK J VERMEIRE P VANMARCK E
Citation
K. Segers et al., IMMUNOREACTIVITY FOR BCL-2 PROTEIN IN MALIGNANT MESOTHELIOMA AND NONNEOPLASTIC MESOTHELIUM, Virchows Archiv, 424(6), 1994, pp. 631-634
Citations number
18
Categorie Soggetti
Pathology
Journal title
Virchows Archiv → ACNP
ISSN journal
09456317
Volume
424
Issue
6
Year of publication
1994
Pages
631 - 634
Database
ISI
SICI code
0945-6317(1994)424:6<631:IFBPIM>2.0.ZU;2-P
Abstract
Immunohistochemical study of bcl-2 protein immunoreactivity in human n on-neoplastic mesothelium (44 cases) and in malignant mesothelioma (62 cases) using a murine monoclonal antibody (clone 124) showed cytoplas mic immunoreactivity for bcl-2 protein in five cases of malignant meso thelioma. Non-neoplastic mesothelium was not immunoreactive. Immunorea ctivity for bcl-2 protein does not add useful prognostic information i n malignant mesothelioma since survival times of bcl-2 positive and bc l-2 negative cases did not differ. Nevertheless, the detection of bcl- 2 protein in malignant mesothelioma might be useful for the differenti ation from reactive mesothelium.