K. Matsumuro et al., PARANEOPLASTIC VASCULITIC NEUROPATHY - IMMUNOHISTOCHEMICAL STUDIES ONA BIOPSIED NERVE AND POSTMORTEM EXAMINATION, Journal of internal medicine, 236(2), 1994, pp. 225-230
We studied a patient with paraneoplastic vasculitic neuropathy (PVN) a
ssociated with a carcinoma of the common bile duct, Immunohistochemica
l analy-sis of the biopsied sural nerve showed that the cellular infil
trates in the vascular lesions were composed primarily of CD8-positive
T lymphocytes and macrophages. Pathogenic significance of the T-cell-
mediated immunological reaction was suggested. Post-mortem examination
revealed the absence of systemic vasculitis, which may be a character
istic feature of PVN. The patient responded to immuno-suppressive trea
tment. We discuss the efficacy and the risk of immunosuppressive thera
py for PVN.