Ajhm. Houben et al., THE EFFECTS OF 7-HOUR LOCAL HYPERGLYCEMIA ON FOREARM MACRO AND MICROCIRCULATORY BLOOD-FLOW AND VASCULAR REACTIVITY IN HEALTHY MAN, Diabetologia, 37(8), 1994, pp. 750-756
Citations number
31
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
Animal studies suggest that hyperglycaemia directly affects local bloo
d now and vascular reactivity. We studied the effects of 7 h of local
forearm hyperglycaemia, on forearm (muscle) and skin microcirculatory
blood now in 12 healthy men. Furthermore, the effects of this local hy
perglycaemia on forearm vasoreactivity to noradrenaline were studied.
Using the perfused forearm technique, a local hyperglycaemia of approx
imately 16 mmol/l was induced by continuous intraarterial infusion of
5% glucose. All subjects received both glucose and placebo (0.9% Nacl)
infusions on two different occasions, in random order and blinded for
the subjects. Forearm (muscle) blood flow and vascular reactivity to
noradrenaline were measured using venous occlusion plethysmography. Sk
in microcirculatory blood flow was evaluated using intravital capillar
y microscopy (nutritive blood now) and laser-Doppler fluxmetry (thermo
regulatory blood flow). Measurements were performed at baseline, after
4 h, and after 7 h of intraarterial glucose or placebo infusion. Duri
ng local glucose infusion there was a slight increase in the levels of
insulin, C-peptide, systemic glucose, and blood pressure, compared to
the placebo experiments. No differences were observed in forearm bloo
d flow and laser-Doppler flux ratio (infused: contralateral arm), as w
ell as in capillary blood cell velocity between glucose and placebo ex
periments. Noradrenaline produced similar reductions in forearm blood
flow ratio during glucose and placebo experiments. We conclude that in
contrast to animal studies, local hyperglycaemia (approximate to 16 m
mol/l) for 7 h does not affect forearm macro and microcirculatory bloo
d flow or vascular reactivity to noradrenaline in man.