GROWTH-INHIBITION OF TRYPANOSOMA-CRUZI AND LEISHMANIA-DONOVANI INFANTUM BY DIFFERENT SNAKE-VENOMS - PRELIMINARY IDENTIFICATION OF PROTEINS FROM CERASTES CERASTES VENOM WHICH INTERACT WITH THE PARASITES

Authors
FERNANDEZGOMEZ R ZERROUK H SEBTI F LOYENS M BENSLIMANE A OUAISSI MA
Citation
R. Fernandezgomez et al., GROWTH-INHIBITION OF TRYPANOSOMA-CRUZI AND LEISHMANIA-DONOVANI INFANTUM BY DIFFERENT SNAKE-VENOMS - PRELIMINARY IDENTIFICATION OF PROTEINS FROM CERASTES CERASTES VENOM WHICH INTERACT WITH THE PARASITES, Toxicon, 32(8), 1994, pp. 875-882
Citations number
23
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
32
Issue
8
Year of publication
1994
Pages
875 - 882
Database
ISI
SICI code
0041-0101(1994)32:8<875:GOTALI>2.0.ZU;2-S
Abstract
Venom from three different snake species was tested in vitro against t he protozoan parasites Trypanosoma cruzi and Leishmania donovani infan tum. Two of them, Cerastes cerastes and Naja haje, exerted a significa nt growth inhibition of T. cruzi and L. d. infantum parasites. Heating of the venoms abolished their activity, suggesting that the active fa ctors are thermolabile. Incubation of parasites with I-125-labelled C. cerastes venom proteins allowed preliminary identification of compone nts which interact preferentially with the pathogens.