MAMMALIAN EXCHANGERS AND CO-TRANSPORTERS

In the past year, novel mammalian exchanger and co-transporter isoform s have been characterized. Specialized subdomains within these oligome ric transporters have been shown to be involved in biosynthesis, targe ting, transport and regulation. Progress on the structural front has b een limited due to the lack of high-resolution structures, but transpo rt mutants responsible for disease states continue to be identified.