COMPARISON OF THE EFFICACY AND SAFETY OF CEFTIBUTEN AND CEFACLOR IN THE TREATMENT OF ACUTE BACTERIAL BRONCHITIS

In a multicenter, international study of 620 adult patients with acute bacterial bronchitis or acute bacterial exacerbation of chronic bronc hitis, the efficacy and safety of a 400-mg once-daily dosage of ceftib uten was compared with cefaclor 250 mg three times daily. In terms of both bacteriologic and clinical efficacy, the two treatments were simi lar, with elimination of the infecting organism in 88% and 87% of pati ents receiving ceftibuten and cefaclor, respectively. Clinical outcome was successful in 91% and 92% of patients receiving ceftibuten and ce faclor, respectively. The pattern of adverse experiences in the two tr eatment groups was similar, with gastrointestinal effects being most f requently reported. The results of this study demonstrate the effectiv eness of once-daily ceftibuten in the treatment of acute bacterial bro nchitis and acute bacterial exacerbations of chronic bronchitis and co nfirm that 400 mg ceftibuten once daily is as effective as 250 mg cefa clor given three times a day.