ASYMMETRIC CATALYTIC REDUCTION OF PROCHIRAL KETONES WITH SUPPORTED METAL-COMPLEXES

Authors
GAMEZ P FACHE F LEMAIRE M
Citation
P. Gamez et al., ASYMMETRIC CATALYTIC REDUCTION OF PROCHIRAL KETONES WITH SUPPORTED METAL-COMPLEXES, Bulletin de la Societe chimique de France, 131(5), 1994, pp. 600-602
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology,Chemistry
Journal title
Bulletin de la Societe chimique de France → ACNP
ISSN journal
00378968
Volume
131
Issue
5
Year of publication
1994
Pages
600 - 602
Database
ISI
SICI code
0037-8968(1994)131:5<600:ACROPK>2.0.ZU;2-O
Abstract
Several prochiral ketones have been reduced by hydride-transfer reduct ion catalyzed by a non-covalently bonded supported catalyst. The react ion gave up to 99% enantiomeric excess at 100% conversion in the case of methyl phenyl-pyruvate. Furthermore, with other substrates an incre ase in the enantiomeric excess was obtained without a decrease in conv ersion. This was achieved by using a continuous flow reactor.