SOLVATION OF LARGE MOLECULES - SOME EXACT RESULTS ON THE DEPENDENCE ON VOLUME AND SURFACE-AREA OF THE SOLUTE

The solvation Gibbs and Helmholtz energies are evaluated exactly in tw o model systems. One is a modification of an interstitial model for wa ter, the second is; a non ideal gas mixture within the second virial a pproximation. In both systems the general form of the solvation Gibb's energy of a large solute s is Delta G(s) = aV(s) + bA(s), where V-s and A(s) are the volume and surface area of the solute s. We also show that this general form is likely to hold true in any real solution.