CHRONIC HYPOXIA AFFECTS PERIPHERAL AND CENTRAL VASOACTIVE INTESTINAL PEPTIDE-LIKE IMMUNOREACTIVITY IN THE RAT

Authors
PONCET L DENOROY L DALMAZ Y PEQUIGNOT JM JOUVET M
Citation
L. Poncet et al., CHRONIC HYPOXIA AFFECTS PERIPHERAL AND CENTRAL VASOACTIVE INTESTINAL PEPTIDE-LIKE IMMUNOREACTIVITY IN THE RAT, Neuroscience letters, 176(1), 1994, pp. 1-4
Citations number
24
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
176
Issue
1
Year of publication
1994
Pages
1 - 4
Database
ISI
SICI code
0304-3940(1994)176:1<1:CHAPAC>2.0.ZU;2-I
Abstract
The influence of long-term hypoxia on vasoactive intestinal peptide-li ke immunoreactivity (VIP-LI) in discrete brain areas and peripheral st ructures was assessed by RIA. Rats were exposed to normobaric hypoxia (10% O-2 -90% N-2) for 14 days. VIP-LI was significantly increased in carotid bodies of hypoxic animals (204% vs. normoxic animals). On the other hand, VIP-LI was decreased in the anterior pituitary (-68%), sup rachiasmatic nuclei (-29%) and periventricular nuclei (-26%). No signi ficant variation in VIP-LI was observed in other peripheral structures and discrete brain areas studied. These results suggest that long-ter m hypoxia induces alterations in VIP systems implicated in chemorecept ion, biological rhythms and neuroendocrine functions.