EFFECTIVE INDUCTION OF PREGNANCY BLOCK BY ELECTRICAL-STIMULATION OF THE MOUSE ACCESSORY OLFACTORY-BULB COINCIDENT WITH PROLACTIN SURGES

Electrical stimulation (0.33 Hz, 0.2 mA) applied bilaterally to the ac cessory olfactory bulb (AOB) of newly mated female mice revealed that stimulation for 4 h was sufficient to produce pregnancy block providin g stimulation is given for two separate 2-h periods coincident with pr olactin surges. Stimulation for two 1-h periods coincident with prolac tin surges or two 2-h periods between prolactin surges was without eff ect. These results indicate that electrical stimulation of the AOB can faithfully reproduce pheromone-induced pregnancy block and support th e view that prolactin is the hormone mainly responsible for the olfact ory block to pregnancy.