DAPSONE ATTENUATES KAINIC ACID-INDUCED SEIZURES IN RATS

We tested the ability of dapsone (4,4'-diamino-diphenyl sulfone) to at tenuate kainic acid-induced seizures. We observed that 9.375 and 12.5 mg/kg doses of dapsone administered 30 min before a single kainic acid (10 mg/kg) i.p. injection were able to decrease the time of electroen cephalographic seizures by 52% and 82%, respectively, as compared with rats administered with 10 mg/kg kainic acid only. The 12.5 mg/kg dose of dapsone was also able to diminish both kainic acid-evoked body and head shakes (58%) and kainic acid-induced mortality (75%). These resu lts suggest that dapsone could be used in clinical trials as anticonvu lsant.