EFFECTS OF FRUCTOSE-1,6-DIPHOSPHATE ON THE ACTIVITY OF RAT-LIVER NITRIC-OXIDE SYNTHASE IN-VITRO

Authors
MIHAS AA MALIAKKAL RJ MIHAS TA KANJI VK MARKOV AK
Citation
Aa. Mihas et al., EFFECTS OF FRUCTOSE-1,6-DIPHOSPHATE ON THE ACTIVITY OF RAT-LIVER NITRIC-OXIDE SYNTHASE IN-VITRO, Pharmacology, 54(1), 1997, pp. 43-48
Citations number
26
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology → ACNP
ISSN journal
00317012
Volume
54
Issue
1
Year of publication
1997
Pages
43 - 48
Database
ISI
SICI code
0031-7012(1997)54:1<43:EOFOTA>2.0.ZU;2-M
Abstract
Fructose-1,6-diphosphate (FDP) was found to cause significant stimulat ion of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its con stitutive counterpart. Furthermore, FDP restored rat liver inducible N OS levels following their depletion by carbon tetrachloride (CCl4). Th is finding may have further practical implications in hepatoprotection from various noxious chemical and biological agents.