A number of elephants previously captured in the Kruger National Park
developed a pink frothy discharge from the external nares. Some of the
se elephants subsequently died and histopathological examinations indi
cated severe lung oedema. In view of the current hypothesis that high
blood pressure could be a causative factor, arterial blood pressure wa
s measured in elephants immobilized with etorphine alone (n = 71) and
with etorphine/azaperone (n = 109) and carfentanil/azaperone (n = 26)
mixtures. Arterial blood pressure was found to be significantly lower
in the groups immobilized with azaperone mixtures than in the group im
mobilized with etorphine alone (p < 0,05). In addition, no cases of lu
ng oedema were observed in animals immobilized with etorphine/azaperon
e and carfentanil/azaperone mixtures. It is strongly recommended, ther
efore, that azaperone be added to immobilization mixtures when elephan
ts are subjected to herding prior to darting.