APPLICATIONS OF QUANTITATIVE STRUCTURE-PROPERTY RELATIONSHIPS TO PHARMACEUTICS

Authors
DEARDEN JC
Citation
Jc. Dearden, APPLICATIONS OF QUANTITATIVE STRUCTURE-PROPERTY RELATIONSHIPS TO PHARMACEUTICS, Chemometrics and intelligent laboratory systems, 24(2), 1994, pp. 77-87
Citations number
19
Categorie Soggetti
Computer Application, Chemistry & Engineering","Instument & Instrumentation","Chemistry Analytical","Computer Science Artificial Intelligence","Robotics & Automatic Control
Journal title
Chemometrics and intelligent laboratory systems → ACNP
ISSN journal
01697439
Volume
24
Issue
2
Year of publication
1994
Pages
77 - 87
Database
ISI
SICI code
0169-7439(1994)24:2<77:AOQSRT>2.0.ZU;2-X
Abstract
Most correlation analysis studies of drugs are concerned with the corr elation of in-vivo or in-vitro biological activity with physicochemica l or structural molecular parameters. However, it is also important to be able to predict such properties as solubility, melting and boiling points, adsorption behaviour, stability to degradation, viscosity, su rface tension and dissolution behaviour, particularly for formulation purposes. This paper reviews the published research in each of these a reas, and makes recommendations for further work.