ACIDITY OF THE ENVIRONMENT AND INTRACELLULAR-DISTRIBUTION OF IONIZABLE SUBSTANCES

Authors
PIRSELOVA K BALAZ S
Citation
K. Pirselova et S. Balaz, ACIDITY OF THE ENVIRONMENT AND INTRACELLULAR-DISTRIBUTION OF IONIZABLE SUBSTANCES, Chemometrics and intelligent laboratory systems, 24(2), 1994, pp. 193-196
Citations number
11
Categorie Soggetti
Computer Application, Chemistry & Engineering","Instument & Instrumentation","Chemistry Analytical","Computer Science Artificial Intelligence","Robotics & Automatic Control
Journal title
Chemometrics and intelligent laboratory systems → ACNP
ISSN journal
01697439
Volume
24
Issue
2
Year of publication
1994
Pages
193 - 196
Database
ISI
SICI code
0169-7439(1994)24:2<193:AOTEAI>2.0.ZU;2-A
Abstract
The description of the bioactivity-hydrophobicity-acidity profiles for monovalent acids or bases represents an application of our published treatment of distribution of ionisable compounds undergoing eliminatio n in biological systems. The approach is applied to the literature dat a on growth inhibition of Sarcina lutea by lincomycins. The model exhi bits satisfactory agreement with the experimental data. The results in dicate that incorporation of elimination into the pseudo-equilibrium m odel improves its quality.