Sclerosing peritonitis (SP) is an uncommon and devastating problem whi
ch involves the visceral and parietal peritoneal surfaces of the abdom
inal cavity. SP has been reported in association with peritoneal dialy
sis, with medications, and following peritonitis. No clear etiology or
preventative treatment exists for this unusual problem. Herein, we re
port 3 cases with the unusual aspect of apparent progression of this f
ibrotic and sclerosing process after the termination of the peritoneal
dialysis and successful renal transplantation. Each of these cases re
sulted in a mechanical small bowel obstruction secondary to a densely
fibrosing and encasing peel of reactive connective tissue visibly diff
erent from the usual postoperative adhesions. Sclerosing peritonitis s
hould be included in the differential diagnosis of a current peritonea
l dialysis patient who exhibits signs of partial small bowel obstructi
on with a continual decrease in peritoneal clearance and/or successful
ly transplanted patients who had utilized peritoneal dialysis therapy
in the past and now exhibit signs and symptoms of a mechanical small b
owel obstruction.