BIOSYNTHESIS OF THE PSEUDOBACTIN CHROMOPHORE FROM TYROSINE

Authors
NOWAKTHOMPSON B GOULD SJ
Citation
B. Nowakthompson et Sj. Gould, BIOSYNTHESIS OF THE PSEUDOBACTIN CHROMOPHORE FROM TYROSINE, Tetrahedron, 50(33), 1994, pp. 9865-9872
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
33
Year of publication
1994
Pages
9865 - 9872
Database
ISI
SICI code
0040-4020(1994)50:33<9865:BOTPCF>2.0.ZU;2-X
Abstract
Biosynthetic studies have shown the incorporation of DL-[2,3,3-H-2(3)] -tyrosine into the chromophore of pseudobactin, a siderophore produced by Pseudomonas fluorescens B 10. A subsequent feeding using DL-[2',5' ,6'- H-2(3)]-3,4-dihydroxyphenylalanine showed no incorporation of the label, suggesting that oxidation of the aryl ring occurs after the in corporation of tyrosine. The C-13 NMR assignments of pseudobactin are also reported herein.