We studied the electrodermal skin conductance responses (SCRs) of 36 s
ubjects with well-characterized lesions in various regions of the cere
bral hemispheres. Several lesion loci were consistently associated wit
h defective electrodermal responding: the ventromedial frontal region
(right and left), the right inferior parietal region, and the anterior
cingulate gyrus (right and left). Our findings provide direct informa
tion regarding neural correlates of skin conductance responses in huma
ns.