RELATIONSHIP BETWEEN SUPEROXIDE-DISMUTASE AND MELANIN IN A PATHOGENICFUNGUS

Authors
JACOBSON ES JENKINS ND TODD JM
Citation
Es. Jacobson et al., RELATIONSHIP BETWEEN SUPEROXIDE-DISMUTASE AND MELANIN IN A PATHOGENICFUNGUS, Infection and immunity, 62(9), 1994, pp. 4085-4086
Citations number
18
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
62
Issue
9
Year of publication
1994
Pages
4085 - 4086
Database
ISI
SICI code
0019-9567(1994)62:9<4085:RBSAMI>2.0.ZU;2-G
Abstract
Since melanin is considered a virulence factor in Cryptococcus neoform ans, its suppression at 37 degrees C has been perplexing. We now show an opposite thermal regulation of superoxide dismutase (SOD), consiste nt with a compensatory mechanism. Moreover, we demonstrate normal SOD and catalase levels in albino, oxygen-sensitive mutants. These results suggest that melanin is an antioxidant factor comparable in importanc e to SOD.