The variability among subjects of the hepatic activities of O-sulphotr
ansferase towards dopamine, p-nitrophenol, testosterone and ethinyloes
tradiol and of N-sulphotransfeiase with 1,2,3,4-tetrahydroisoquinoline
(TIQ) as substrate is described. The rates of testosterone and TIQ su
lphation were higher in men than women whereas those of ethinyloestrad
iol, dopamine and p-nitrophenol were similar in both sexes. The sulpho
transferase activities towards p-nitrophenol and dopamine were positiv
ely skewed whereas those towards ethinyloestradiol approached normalit
y. The coefficients of variations for the sulphotransferase activities
ranged between 34% and 62% indicating a considerable variability amon
g subjects. The rates of dopamine-, TIQ- and p-nitrophenol-sulphation
were measured in the mucosa of the human intestine, and the duodenum/l
iver ratios were 10, 0.9 and 0.1, respectively. Thus the contribution
of the intestine in the sulphation of xenobiotics is substrate depende
nt.