REACTIVITY OF 6-AMINOPYRIMIDIN-4-(3H)-ONES TOWARDS DIMETHYL ACETYLENEDICARBOXYLATE (DMAD) - TANDEM DIELS-ALDER RETRO-DIELS-ALDER (DA RDA) REACTION IN THE SYNTHESIS OF 2-AMINOPYRIDINES/

Authors
COBO J GARCIA C MELGUIZO M SANCHEZ A NOGUERAS M
Citation
J. Cobo et al., REACTIVITY OF 6-AMINOPYRIMIDIN-4-(3H)-ONES TOWARDS DIMETHYL ACETYLENEDICARBOXYLATE (DMAD) - TANDEM DIELS-ALDER RETRO-DIELS-ALDER (DA RDA) REACTION IN THE SYNTHESIS OF 2-AMINOPYRIDINES/, Tetrahedron, 50(34), 1994, pp. 10345-10358
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
34
Year of publication
1994
Pages
10345 - 10358
Database
ISI
SICI code
0040-4020(1994)50:34<10345:RO6TDA>2.0.ZU;2-Q
Abstract
The reactions of 6-aminopyrimidin-4-(3)-one derivatives, 1a-d, with DM AD, 2, are discussed in this paper. 2-aminopyridines, 3, and 6-amino-5 -vinylpyrimidin-4-(3)-ones, 4 and 5, have been obtained as main produc ts, which can be explained on the basis of DA/RDA reactions, or Michae l Addition on pyrimidine derivatives.