In chronical proximal sesamoid bone lameness it is difficult to locali
se the exact site of pain. A specific diagnostic analgesia is not avai
lable because of a deficiency of detailed information about the nerve
supply to the proximal sesamoid bones and surrounding area. A macrosco
pic study of the nerve distribution to the proximal sesamoid bones of
10 foals and 5 adult horses revealed that these bones are innervated b
y two branches, in this study called the medial and lateral sesamoidea
n nerve, respectively, originating from the medial and lateral palmar
nerve. Histology of the left forelimbs of two fetuses and one foal con
firmed the macroscopic findings. Additionally, histology of ten proxim
al sesamoid bones of adult horses showed that myelinated nerve fibres
are present in the nutrient foramina and in the trabecular bone, accom
panying the larger arteries. This study provides possibilities for fut
ure diagnostics of proximal sesamoid bone lameness by specific local p
erineural analgesia.