SAFETY AND EFFECTIVENESS OF AN AGGRESSIVE AND INDIVIDUALIZED BATH-PUVA REGIMEN IN THE TREATMENT OF PSORIASIS

Background: The optimal therapeutic regimen of bath-PUVA therapy of ps oriasis is still under debate. Objective: We investigated the safety a nd efficacy of an aggressive and individualized bath-PUVA regimen. Met hods: Two closely matched groups of 22 psoriatic patients were treated either with 30-min baths in 0.0003% 8-methoxypsoralen (8-MOP) aqueous solution or oral administration of the drug. According to the standar d European regimen, treatments were delivered 4 times a week starting with the minimal phototoxic dose. Results: Complete clearing or marked improvement was observed in all the patients. However, with bath-PUVA , the same therapeutic effect required smaller cumulative UVA doses (3 9.3 +/- 15.8 vs. 123.8 +/- 39.9 J/cm(2)) and lower numbers of exposure s (15.2 +/- 4.4 vs. 20.6 +/- 4.2). Both differences were significant a t the 0.01 level (Student's t test). Gastro-intestinal side-effects we re of course restricted to oral 8-MOP. The incidences of bums and prur itus were similar. Conclusion: Using an aggressive and individualized schedule, bath-PUVA therapy showed a greater efficacy than oral PUVA t herapy while being just as safe.