H. Matsukura et al., EFFECTS OF NC-1300-O-3 ON GASTRIC MUCUS SECRETION AND PROSTAGLANDIN RELEASE IN RATS, Japanese Journal of Pharmacology, 65(4), 1994, pp. 319-326
We investigated the effect of NC-1300-O-3 on gastric mucus secretion a
nd prostaglandin release into the gastric lumen in rats. NC-1300-O-3 f
ollowing single or repeated administration for up to 4 weeks significa
ntly increased the hexose content in the gastric lumen at 10 to 100 mg
/kg, p.o. Omeprazole and cimetidine at doses that strongly inhibited g
astric acid secretion had no effect on the hexose content following si
ngle or repeated administration for 8 days. When administered repeated
ly for 8 days, NC-1300-O-3, omeprazole and cimetidine significantly de
creased the hexosamine content in gastric surface mucosa, but signific
antly increased gastric mucus secretion was observed at the same time
only with NC-1300-O-3, indicating that this agent has a profile of act
ion on gastric mucus metabolism different from those of omeprazole and
cimetidine. NC-1300-O-3 at 10 and 30 mg/kg, p.o. and omeprazole at 30
mg/kg, p.o. increased the release of prostaglandins into the gastric
lumen, and this was markedly inhibited by pretreatment with indomethac
in, suggesting that these agents may enhance prostaglandin biosynthesi
s in the gastric mucosa. From these results, it seems that the enhance
ment of NC-1300-O-3 on gastric mucus secretion and prostaglandin biosy
nthesis in the gastric mucosa contribute to the antiulcer effect of NC
-1300-O-3.