CONFORMATIONAL-ANALYSIS BY NMR-SPECTROSCOPY OF 2'-DEOXY-2'-C-ALKYLNUCLEOSIDES - BUILDING-BLOCKS OF NEW ANTISENSE FRAGMENTS

Authors
CICERO DO IRIBARREN AM BAZZO R
Citation
Do. Cicero et al., CONFORMATIONAL-ANALYSIS BY NMR-SPECTROSCOPY OF 2'-DEOXY-2'-C-ALKYLNUCLEOSIDES - BUILDING-BLOCKS OF NEW ANTISENSE FRAGMENTS, Applied magnetic resonance, 7(1), 1994, pp. 95-105
Citations number
19
Categorie Soggetti
Spectroscopy,"Physics, Atomic, Molecular & Chemical
Journal title
Applied magnetic resonance → ACNP
ISSN journal
09379347
Volume
7
Issue
1
Year of publication
1994
Pages
95 - 105
Database
ISI
SICI code
0937-9347(1994)7:1<95:CBNO2>2.0.ZU;2-Z
Abstract
The conformation in solution of new modified nucleosides bearing branc hed-chain sugars used as building blocks for antisense oligonucleotide s is investigated by NMR spectroscopy. Within a classical approach to the conformational study of these molecules, a new methodology is adop ted, which is capable of exploring all the possibilities, for a given conformational model, that are compatible with the experimental data. The relationship between conformation of the monomers and hybridizatio n properties of the corresponding oligonucleotides is examined.