EFFECT OF TOPICAL PREPARATION OF MYCOPHENOLIC-ACID ON EXPERIMENTAL ALLERGIC CONTACT-DERMATITIS OF GUINEA-PIGS INDUCED BY DINITROFLUOROBENZENE

The effects of a topical preparation of mycophenolic acid on the exper imental allergic contact dermatitis induced by dinitrofluorobenzene wa s investigated. Visual assessment of skin reactions showed significant efficacy of a topical preparation of mycophenolic acid. This efficacy appeared from the early stage and endured up to 3 days. Morphological changes in the epidermis and dermis layers of animals treated with a mycophenolic acid cream were moderate compared with that in animals tr eated with vehicle only. In particular, hyperkeratosis was strongly su ppressed. Since suppression of inflammatory cell infiltration was also observed, this efficacy might reach to the epidermis and dermis layer .