Reactive arthritis, or Reiter's disease, characteristically affects th
e joints of the lower limbs in an asymmetrical pattern. Usually it doe
s not affect the cervical spine, and atlantoaxial subluxations are the
exception. This paper describes the case of an HLA-B27-positive femal
e patient with a sexually acquired reactive arthritis where a non-redu
cible atlantoaxial subluxation was present. The patient was followed f
rom age 27 to 41. By the age of 38, an anterior decompression of the c
ervico-medullary junction was performed by a transoral approach; in a
second stage, the patient underwent an occipito-cervical posterior fus
ion. The pathological study revealed a non-specific and chronic inflam
matory infiltrate.