LIVER CALCIUM HOMEOSTASIS MODIFICATION BY IRON - A PROBABLE FACTOR INITS CARCINOGENESIS

Low molecular weight iron complexes, ferric lactate and ferric ATP com plex, induce an important increase of Ca2+-uptake by liver. The activi ty of ferric lactate increased by the presence of sodium ATP, and the steady high effect of ferric-ATP complex appear to indicate that ATP m ight play an important role in the in vivo formation of low molecular weight iron complexes that can Induce the modification of the hepatocy tes calcium homeostasis the event that might be one of the factors tri ggering the malignant transformation.