IMMUNE REACTIVE PROTEINS IN RENAL-CELL CARCINOMA PATIENTS TREATED BY IFN-ALPHA ALONE OR IN COMBINATION WITH VINBLASTINE

Citation
Z. Juranic et al., IMMUNE REACTIVE PROTEINS IN RENAL-CELL CARCINOMA PATIENTS TREATED BY IFN-ALPHA ALONE OR IN COMBINATION WITH VINBLASTINE, Neoplasma, 41(4), 1994, pp. 229-232
Citations number
19
Categorie Soggetti
Oncology
Journal title
ISSN journal
00282685
Volume
41
Issue
4
Year of publication
1994
Pages
229 - 232
Database
ISI
SICI code
0028-2685(1994)41:4<229:IRPIRC>2.0.ZU;2-7
Abstract
Immunoreactive proteins - serum immunoglobulins and immune complexes w ere evaluated in renal cell carcinoma (RCC) patients. The analyses wer e done after radical nephrectomy before, at the end, and six months af ter the therapy, with IFN alpha alone (in patients in Stage II) or IFN alpha in the combination with vinblastine (in patients in Stage III a nd IV of the disease). Data obtained before immuno- or immunochemother apy show significant increase in IgG and IgA concentrations in RCC pat ients in all stages of the disease investigated - in comparison to con trols, while circulating immune complexes were significantly elevated only in patients in the advanced Stages of the disease (III and IV). T he unchanged IgM level was found in all untreated RCC patients regardi ng the controls. Immuno- or immunochemotherapy did not affect the immu noreactive proteins (Ig and CIC) in the investigated patients, without respect to their clinical response to the applied therapy.