AN INVESTIGATION ON THE HEPATOPROTECTIVE ACTIVITY OF GYMNOSPORIA-MONTANA

The methanol extract of the defatted leaves of Gymnosporia montana was evaluated for hepatoprotective activity by noting its effect on carbo n tetrachloride (CCl4)-induced changes in liver cytoarchitecture and a lterations in certain biochemical parameters. The main parameters stud ied were transaminase activity, lipid constituents of serum and liver, orosomucoid level in serum, and liver glycogen and phospholipid conte nts. The extract administration led to a significant reversal of the m ajority of the altered biochemical parameters. Besides, a significant antagonism of the CCl4-induced changes in the liver cytoarchitecture w as also observed. The results confirm the presence of hepatoprotective activity in the plant material.