CAFFEOYLQUINIC ACIDS AND SOME BIOLOGICAL-ACTIVITIES OF PLUCHEA-SYMPHYTIFOLIA

From the aerial parts of Pluchea symphytifolia, four known and two new caffeoylquinic acids, 1,3,4,5-tetra-O-caffeoylquinic acid and yclobut ane-1,2-dicarbonyl]-4,5-di-O-caffeoylquinic acid, and two flavonols we re isolated and their structures elucidated by mass and NMR spectrosco py and by chemical degradation. The aqueous extract had weak antibacte rial and weak antisecretory effects; the lipophilic extract showed a m odest anthelmintic activity. The higher caffeoylated quinic acids part icipated in the antibacterial and anthelmintic effect of the extracts.