THE ABSENCE OF A PHARMACOKINETIC INTERACTION BETWEEN ASPIRIN AND THE ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR BENAZEPRIL IN HEALTHY-VOLUNTEERS

Potential effects of the coadministration of single doses of aspirin ( 325 mg) and of benazepril hydrochloride (20 mg) on the pharmacokinetic s and the metabolism of these two drugs were evaluated in 12 healthy s ubjects. Plasma concentration profiles of benazepril, its active metab olite benazeprilat, and total salicylic acid were determined together with urinary excretion of benazeprilat, salicylic acid, salicyluric ac id, and salicylate glucuronides. Almost superimposable plasma profiles of benazepril, benazeprilat, and total salicylic acid were achieved w ith the drugs given alone and concomitantly. The coadministration of b enazepril hydrochloride and aspirin did not modify the pharmacokinetic s or the metabolism of the two drugs.