SIGMOID SHAPE OF THE OXYGEN EQUILIBRIUM CURVE AND THE P-50 OF HUMAN HEMOGLOBIN

Authors
KOBAYASHI M SATOH G ISHIGAKI K
Citation
M. Kobayashi et al., SIGMOID SHAPE OF THE OXYGEN EQUILIBRIUM CURVE AND THE P-50 OF HUMAN HEMOGLOBIN, Experientia, 50(8), 1994, pp. 705-707
Citations number
12
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
50
Issue
8
Year of publication
1994
Pages
705 - 707
Database
ISI
SICI code
0014-4754(1994)50:8<705:SSOTOE>2.0.ZU;2-B
Abstract
The fractional saturation of hemoglobin with oxygen was plotted agains t P/P-50 and the slope of the abscissa at 1 was calculated for 38 OEC data sets of human Hb A, There was a linear correlation between the sl ope and the Hill coefficient (n(max)), and the slope was about one-for th that of n(max). This implies that the slope of the abscissa at 1 of Y vs P/P-50 plot can provide information about the magnitude of coope rativity in hemoglobin oxygen binding.