INTERMITTENT HAIR LOSS IN A CHILD WITH PIBI(D)S-SYNDROME AND TRICHOTHIODYSTROPHY WITH DEFECTIVE-DNA REPAIR XERODERMA-PIGMENTOSUM GROUP-D

We describe a girl with photosensitivity (P), ichthyosis (I), brittle hair (B), impaired intelligence (I), possibly decreased fertility (D), and short stature (S). The clinical findings fit into the PIBI(D)S sy ndrome and trichothiodystrophy. A remarkable and probably unique obser vation for this disorder was the intermittent character of the scalp h air loss during infectious periods in this patient. Easy suntanning su ggested photosensitivity and prompted DNA repair studies which demonst rated reduced UV-induced DNA repair synthesis. Subsequent studies have assigned this patient to xeroderma pigmentosum group D and suggested a specific deficiency of 6-4 photoproduct repair. An unaffected child was diagnosed in the next pregnancy of the mother. (C) 1994 Wiley-Liss , Inc.