We compared delayed vasectomy reversals performed in rats using fibrin
glue combined with 3 transmural sutures or a conventional microsurgic
al technique. Forty Sprague-Dawley rats underwent bilateral vasectomy
followed 2 weeks later by bilateral vasovasostomy using fibrin glue or
a conventional microsurgical suture technique. Our protocol evaluated
fertility rates after a 3-week mating period, sperm granuloma formati
on, histological changes at the anastomotic site, longitudinal tensile
strength and mean testicular weight. The fibrin glue technique requir
ed significantly reduced operative lime (p < 0.0005) and showed statis
tically lower tensile strength performance (p < 0.0005). All other par
ameters showed no statistical difference between the two techniques. F
ibrin-glued vasovasostomy is efficient in a delayed protocol and deser
ves further clinical experience.