ANTITUMOR AND CYTOTOXIC SCREEN OF 5,6,7-TRISUBSTITUTED FLAVONES FROM GOMPHRENA-MARTIANA

Authors
POMILIO AB SOLA GAR MAYER AMS RUMI LS
Citation
Ab. Pomilio et al., ANTITUMOR AND CYTOTOXIC SCREEN OF 5,6,7-TRISUBSTITUTED FLAVONES FROM GOMPHRENA-MARTIANA, Journal of ethnopharmacology, 44(1), 1994, pp. 25-33
Citations number
49
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Journal of ethnopharmacology → ACNP
ISSN journal
03788741
Volume
44
Issue
1
Year of publication
1994
Pages
25 - 33
Database
ISI
SICI code
0378-8741(1994)44:1<25:AACSO5>2.0.ZU;2-6
Abstract
An in vivo antitumor screening of extracts of Gomphrena martiana indic ated positive activity in the petroleum ether extract, and its further bioactivity-directed fractionation resulted in a lipophilic flavonoid fraction. Upon inoculation of various doses of 5,6,7-trisubstituted f lavones on two murine tumor lines, Sarcoma 180 and Ehrlich's carcinoma , a decrease of tumor growth was observed. An in vitro KB cultured cel l screen indicated cytotoxicity